Kratom is a stimulant-like substance derived from the Mitragyna speciosa tree. It acts on the central nervous system (CNS) in a similar way to opioids. However, kratom is not approved by the FDA for use in the U.S. Because it has not yet been tested for safety in humans, there is a risk of misuse, addiction, and toxicity. The risks of using kratom include cardiovascular toxicity, liver damage, and drug dependence.
When taking the herb known as kratom, users may experience withdrawal symptoms upon discontinuation. In addition, users should be aware that kratom has a number of interactions with other substances. This is particularly true when used in combination with opioids, alcohol, and benzodiazepines. Consequently, it is important for healthcare practitioners to be able to discuss kratom with their patients and to inform them about potential side effects.
A recent survey of kratom users reveals that more than three-quarters of respondents were concerned about the acute and chronic effects of kratom. Most reported feeling the effects of kratom within minutes and nearly all reported a discontinuation of its effects within a few hours. Many were also worried about their daily obligations and goals.
Several respondents described a “lower threshold dose” of kratom as the lowest effective dose without being too high. Others defined an “upper threshold dose” as the highest effective dose for the desired results. Among those who rated a lower threshold dose, 80% said it was too low, while 8% felt it was too high. Those who rated an upper threshold dose, on the other hand, said it was not too low.
While some kratom consumers report changing dosing routines based on the circumstances, the majority of kratom consumers continue to consume kratom in the same fashion, and most do not change their dosing regimen. Despite this, some kratom users have experienced undesirable effects. These include: sedation, fatigue, sleep disturbance, nausea, and euphoria. Although these effects are not necessarily dangerous, they can be disruptive.
One of the first things a healthcare professional should do when discussing kratom with a patient is to assess their kratom intake. Patients should be encouraged to avoid taking kratom in high doses. As with any other substance, it is possible for individuals to overdose. Dosages should be kept small and used as necessary to achieve therapeutic goals.
A number of factors impact how long a person should wait before taking kratom again. For instance, some individuals take kratom as an alternative to opioids, while others seek pain relief. Regardless of how a person chooses to consume kratom, a variety of effects can be experienced, including: euphoria, weight loss, sedation, a dreamlike state, and stimulation. Moreover, a person can develop a dependency on kratom, and may require medical assistance when stopping its use.
Similarly, the average effective kratom dose is not large. Nevertheless, a number of kratom users have developed physical dependences on it, which can lead to adverse health consequences. Even with the risk of kratom dependency, kratom is an effective alternative to opioids.

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